In 1962 the laboratory of West Germany pharmaceutical company KNOLL created a new antianginal generic Isoptin subsequently received the generic name Verapamil. In June 1966 in the laboratories of the other Germanic company BAYER first samples were synthesized generic, received a brand name Adalat (International Nifedipine).

In 1969 German physiologist Albrecht Fleckenstein, who has studied the pharmacological effects verapamil verapamil suggested the name and kindred mechanism of action of calcium antagonists Antianginal indian drugs. In a broad sense, a substance called calcium antagonists, which eliminate the influence of ionized calcium into cells by influencing the movement of these ions across the membrane of cells, or the binding / release them from the sarcoplasmic reticulum. Calcium antagonists have no antagonistic effects with respect to calcium ions, but only to block its passage into the smooth muscle cells through special channels, which is why in recent years to represent them use the term slow calcium channel blockers (BMKK).

During his nearly 30-year history of calcium antagonists have received great recognition in Online Pharmacy Without Prescription practice. First of all, it is an effective antihypertensive and antianginalnye funds. By the essential qualities of this group of generics is attributed to metabolic neutrality. They do not affect lipid metabolism, in carbohydrate metabolism and insulin sensitivity did not alter the electrolyte balance.

The action of another class of new prokinetikov – motilinovyh receptor agonists, based on the impact motilina on the motor activity of the digestive tract. Antibiotic Erythromycin mimics the effects motilina, increases the pressure in the lower esophageal sphincter and increases the rate of gastric evacuation. Erythromycin and other (14 members) macrolides inhibit the binding of competitive motilina with its receptors on the smooth muscles of the digestive tract and may act as agonists motilina. Established that motilinovye high density of receptors available on the smooth muscles of the stomach, small and large bowel. Erythromycin increases the speed of evacuation from the stomach with a number of pathological conditions, particularly in gastroparesis in diabetics and patients with progressive systemic scleroderma, reduces the transit time of intestinal contents in the proximal colon.

The next group of generics – drugs are interacting with 5-gidroksitriptaminovymi (5-HT) receptors. Biological effects of 5-hydroxytryptamine due to its interaction with specific receptors: 5-HT-1, 5-HT-2, 5-HT-3, 5-HT-4. One of the modulators of serotonin receptors was generic Tropisetron. Preparation for a long time and significantly increases the pressure in the lower esophageal sphincter, accelerates the evacuation of the stomach. In the colon, increases the duration of oral tsekalnogo and colonic transit, reduces the tonic component gastrokolicheskogo response to food and normalizes the tone of the colon. In clinical antagonists against 5-BIAS-receptors are effective in treating patients with irritable bowel syndrome with predominant diarrhea.

Thus, currently practicing physicians have a sufficient arsenal of modern prokineticheskih drugs for the management treatment of dyskinesias of different gastrointestinal tract. Calcium antagonists and beta-blockers, presented in the pharmaceutical market.

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